Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tezosentan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA known ✓ | P25101 | 20/20 | 0.79 |
| ▸ | EDNRB known ✓ | P24530 | 19/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tezosentan SCHEMBL29409604 | 0.99 | EDNRA (0.80) | EDNRAEDNRB | |
| Tezosentan SCHEMBL4524 | 0.99 | EDNRA (0.80) | EDNRAEDNRB | |
| Tezosentan SCHEMBL387772 | 0.99 | EDNRA (0.79) | EDNRAEDNRB | |
| Tezosentan SCHEMBL1230886 | 0.99 | EDNRA (0.79) | EDNRAEDNRB | |
| SCHEMBL7503358 | 0.92 | EDNRA (0.69) | EDNRAEDNRB | |
| Clazosentan SCHEMBL6974629 | 0.92 | EDNRA (0.78) | EDNRAEDNRB | |
| Clazosentan SCHEMBL29581457 | 0.92 | EDNRA (0.78) | EDNRAEDNRB | |
| Clazosentan SCHEMBL29581324 | 0.91 | EDNRA (0.79) | EDNRAEDNRB | |
| Clazosentan SCHEMBL1983603 | 0.91 | EDNRA (0.79) | EDNRAEDNRB | |
| Clazosentan SCHEMBL29379450 | 0.91 | EDNRA (0.79) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | disclosed |
| EP-1060749-B1 | Aqueous pharmaceutical composition comprising Tezosentan | ACTELION PHARMACEUTICALS LTD (CH) | 2003-03-26 | — | — | EP | disclosed |
| EP-1060749-A1 | Aqueous pharmaceutical composition comprising Tezosentan | Actelion Pharmaceuticals Ltd. (CH) | 2000-12-20 | — | — | EP | disclosed |
| EP-0799209-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019459-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |