Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972978 | 0.95 | MEN1 (0.35) | MEN1KMT2ATLR8ALDH1A1TDP1 | |
| SCHEMBL6968588 | 0.94 | MEN1 (0.37) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL6965157 | 0.91 | TLR8 (0.34) | TLR8ALDH1A1TDP1 | |
| SCHEMBL6965480 | 0.91 | POLB (0.44) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL6970813 | 0.90 | KMT2A (0.35) | MEN1KMT2AALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL6962002 | 0.88 | TLR8 (0.36) | KMT2ATLR8ALDH1A1 | |
| SCHEMBL6974514 | 0.88 | MEN1 (0.35) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL6972502 | 0.87 | POLB (0.38) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL7084131 | 0.86 | TLR8 (0.35) | LMNATLR8ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6965579 | 0.86 | HSP90B1 (0.35) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |