Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963789 | 0.82 | KDR (0.56) | PDGFRBKDRCA1CA2CA4 | |
| SCHEMBL7091941 | 0.82 | CHEK1 (0.63) | KDRCA1CA2CA4CA6 | |
| SCHEMBL4808805 | 0.81 | PDGFRB (0.51) | PDGFRBKDRKITCA1CA2 | |
| SCHEMBL4809669 | 0.80 | KDR (0.80) | PDGFRBKDRKITNPC1RET | |
| SCHEMBL4817592 | 0.80 | KDR (0.60) | KDRCHEK1 | |
| SCHEMBL7704738 | 0.77 | CHEK1 (0.64) | KDRRETPDGFRAFLT3TYRO3 | |
| SCHEMBL7698719 | 0.77 | KDR (0.51) | KDRCHEK1 | |
| SCHEMBL7703646 | 0.77 | CHEK1 (0.57) | KDRCHEK1 | |
| SCHEMBL4813573 | 0.76 | KDR (0.75) | KDRKITCHEK1 | |
| SCHEMBL7698409 | 0.73 | KDR (0.49) | KDRKITCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023063-B1 | INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES | ABBOTT GMBH & CO KG (DE) | 2003-09-10 | — | — | EP | disclosed |
| US-6451834-B1 | Indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole derivatives | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-17 | — | — | US | disclosed |