SCHEMBL6965515

SCHEMBL6965515

O=S(=O)(NC1CCN(Cc2ccccc2)CC1)c1ccccc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.85
THRB P10828 1/20 0.77
KMT2A Q03164 7/20 0.73
ALDH1A1 P00352 4/20 0.73
SMN1; SMN2 Q16637 2/20 0.73
CCR3 P51677 1/20 0.68
MAPT P10636 1/20 0.67
MEN1 O00255 4/20 0.65
OPRK1 P41145 1/20 0.64
KDM4E B2RXH2 1/20 0.62
POLB P06746 1/20 0.62
HTR2A P28223 1/20 0.62
HTR1A P08908 3/20 0.62
HTR7 P34969 3/20 0.62
TP53 P04637 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
USP2 O75604 1/20 0.61
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2C19 P33261 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19000608 0.91 HTT (0.79) HTTTHRBKMT2AALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL8783836 0.87 HTT (0.74) HTTTHRBKMT2AALDH1A1SMN1; SMN2
SCHEMBL6787343 0.86 KMT2A (0.98) HTTTHRBKMT2AALDH1A1SMN1; SMN2
SCHEMBL6335815 0.85 HTT (0.67) HTTTHRBKMT2AALDH1A1SMN1; SMN2
SCHEMBL6749008 0.84 HTT (0.65) HTTTHRBKMT2AALDH1A1SMN1; SMN2
SCHEMBL6752179 0.84 HTT (0.65) HTTTHRBKMT2AALDH1A1SMN1; SMN2
SCHEMBL6749288 0.84 HTT (0.65) HTTTHRBKMT2AALDH1A1SMN1; SMN2
SCHEMBL8388011 0.83 HTT (0.68) HTTTHRBKMT2AALDH1A1SMN1; SMN2
SCHEMBL26321286 0.83 HTT (0.68) HTTTHRBKMT2AALDH1A1SMN1; SMN2
SCHEMBL8783990 0.83 HTT (0.67) HTTTHRBKMT2AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0956287-B1 3-ARYL-2-(1-SUBSTITUTED-4-PIPERIDINYL)-1(1-DI)OXO-3H-BENZO D]-ISOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MODULATORS OF NEUROTRANSMITTER FUNCTION AVENTIS PHARMA INC (US) 2003-08-13 EP disclosed
EP-0956287-A1 3-ARYL-2-(1-SUBSTITUTED-4-PIPERIDINYL)-1(1-DI)OXO-3H-BENZO D]-ISOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MODULATORS OF NEUROTRANSMITTER FUNCTION HOECHST MARION ROUSSEL, INC. (US) 1999-11-17 EP disclosed
US-5972963-A AN ANTIDEPRESSANT, MODULATORS OF NEUROTRANSMITTER FUNCTION SUCH AS SEROTONERGIC AND ADRENERGIC, DOPAMINERGIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1999-10-26 US disclosed
WO-1998028295-A1 3-ARYL-2-(1-SUBSTITUTED-4-PIPERIDINYL)-1(1-DI)OXO-3H-BENZO[D]-ISOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MODULATORS OF NEUROTRANSMITTER FUNCTION HOECHST MARION ROUSSEL, INC. (US) 1998-07-02 WO disclosed