Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.53 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.53 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 12/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756919 | 0.87 | STIM1 (0.50) | SMN1; SMN2LMNATSHRHTTNPSR1 | |
| SCHEMBL758485 | 0.87 | STIM1 (0.54) | SMN1; SMN2LMNATSHRHTTNPSR1 | |
| SCHEMBL761267 | 0.86 | STIM1 (0.49) | SMN1; SMN2LMNATSHRHTTNPSR1 | |
| SCHEMBL758944 | 0.84 | STIM1 (0.76) | SMN1; SMN2LMNAHTTNPSR1STIM1 | |
| SCHEMBL756846 | 0.84 | STIM1 (0.62) | SMN1; SMN2LMNASTIM1ORAI1ORAI3 | |
| SCHEMBL755784 | 0.83 | STIM1 (0.61) | SMN1; SMN2LMNAHTTNPSR1STIM1 | |
| SCHEMBL760682 | 0.83 | STIM1 (0.54) | SMN1; SMN2LMNATSHRHTTNPSR1 | |
| SCHEMBL758805 | 0.82 | STIM1 (0.53) | SMN1; SMN2LMNASTIM1ORAI1ORAI3 | |
| SCHEMBL757600 | 0.79 | STIM1 (0.71) | SMN1; SMN2LMNATSHRHTTNPSR1 | |
| SCHEMBL24336245 | 0.78 | SMN1; SMN2 (0.66) | SMN1; SMN2LMNATSHRHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421835-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | Glaxo Group Limited (GB) | 2012-02-29 | — | — | EP | disclosed |