SCHEMBL6965799

SCHEMBL6965799

O=c1oc(-c2ccccc2)cc(O)c1Sc1cccc2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGES O14684 4/20 0.51
CYP1A2 P05177 5/20 0.46
CYP1A1 P04798 4/20 0.46
SMN1; SMN2 Q16637 4/20 0.46
ABCG2 Q9UNQ0 3/20 0.46
PAX8 Q06710 2/20 0.46
POLB P06746 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
FYN P06241 1/20 0.46
MAPK3 P27361 1/20 0.46
AHR P35869 1/20 0.46
ALOX5 P09917 2/20 0.45
CYP19A1 P11511 5/20 0.43
CYP1B1 Q16678 5/20 0.43
TP53 P04637 3/20 0.43
CYP3A4 P08684 3/20 0.43
HPGD P15428 3/20 0.43
MAPT P10636 3/20 0.43
ABCB1 P08183 3/20 0.43
KDM4E B2RXH2 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6958076 0.83 SMN1; SMN2 (0.58) PTGESCYP1A2CYP1A1SMN1; SMN2ABCG2
SCHEMBL6963608 0.82 MEN1 (0.50) PTGESCYP1A2CYP1A1SMN1; SMN2ABCG2
SCHEMBL6966155 0.82 SMN1; SMN2 (0.48) PTGESCYP1A2CYP1A1SMN1; SMN2ABCG2
SCHEMBL6958434 0.80 SMN1; SMN2 (0.46) PTGESCYP1A2CYP1A1SMN1; SMN2POLB
SCHEMBL6961039 0.80 SMN1; SMN2 (0.46) PTGESCYP1A2CYP1A1SMN1; SMN2POLB
SCHEMBL7397801 0.79 SMN1; SMN2 (0.54) PTGESCYP1A2CYP1A1SMN1; SMN2ABCG2
SCHEMBL8533692 0.79 SMN1; SMN2 (0.46) PTGESCYP1A2CYP1A1SMN1; SMN2POLB
SCHEMBL6956759 0.79 SMN1; SMN2 (0.45) PTGESCYP1A2CYP1A1SMN1; SMN2ABCG2
SCHEMBL6960421 0.79 KDM4E (0.48) PTGESSMN1; SMN2ABCG2POLBL3MBTL1
SCHEMBL6965647 0.78 SMN1; SMN2 (0.44) PTGESCYP1A2CYP1A1SMN1; SMN2ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729465-B1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE DAVIS & CO (US) 2003-01-22 EP disclosed
US-6005103-A TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS WARNER-LAMBERT COMPANY (US) 1999-12-21 US disclosed
US-5808062-A AIDS THERAPY WARNER-LAMBERT COMPANY (US) 1998-09-15 US disclosed
EP-0729466-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
EP-0729465-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1996-09-04 EP disclosed
WO-1995014013-A1 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed
WO-1995014014-A2 PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS PARKE, DAVIS & COMPANY (US) 1995-05-26 WO disclosed