SCHEMBL6965883

SCHEMBL6965883

COC(=O)C1CCc2cc(OCc3nc(-c4ccccc4)oc3C)ccc2C1O

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.67
PPARA Q07869 18/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6817029 0.82 PPARG (0.85) PPARGPPARA
SCHEMBL3450590 0.76 PPARG (0.62) PPARGPPARA
SCHEMBL14382612 0.76 KDR (0.58) PPARGPPARA
SCHEMBL14382624 0.76 KDR (0.58) PPARGPPARA
SCHEMBL821022 0.75 PPARG (1.00) PPARGPPARA
SCHEMBL20214203 0.75 PPARG (1.00) PPARGPPARA
SCHEMBL20214095 0.75 PPARG (1.00) PPARGPPARA
SCHEMBL821398 0.75 PPARG (1.00) PPARGPPARA
SCHEMBL820661 0.75 PPARG (1.00) PPARGPPARA
SCHEMBL821468 0.75 PPARG (0.89) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0783496-B9 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-09-03 EP disclosed
EP-0783496-B1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-26 EP disclosed
US-5965589-A AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-12 US disclosed
EP-0783496-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-16 EP disclosed
WO-1996005186-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-02-22 WO disclosed