Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966041 | 1.00 | KDM4E (0.39) | KDM4ESMN1; SMN2TDP1L3MBTL1TSHR | |
| SCHEMBL6965168 | 0.80 | KDM4E (0.39) | KDM4ESMN1; SMN2TDP1L3MBTL1TSHR | |
| SCHEMBL6965172 | 0.80 | KDM4E (0.39) | KDM4ESMN1; SMN2TDP1L3MBTL1TSHR | |
| SCHEMBL2812357 | 0.80 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2TDP1L3MBTL1TSHR | |
| SCHEMBL2997336 | 0.80 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2TDP1L3MBTL1TSHR | |
| SCHEMBL2812354 | 0.80 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2TDP1L3MBTL1TSHR | |
| SCHEMBL129118 | 0.74 | TSHR (0.57) | SMN1; SMN2TDP1L3MBTL1TSHRMAPT | |
| SCHEMBL9019942 | 0.73 | KDM4E (0.46) | KDM4ESMN1; SMN2TDP1L3MBTL1MAPT | |
| SCHEMBL9334916 | 0.72 | NPC1 (0.49) | KDM4ESMN1; SMN2LMNAALDH1A1MEN1 | |
| SCHEMBL9334924 | 0.72 | NPC1 (0.49) | KDM4ESMN1; SMN2LMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |