Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 8/20 | 0.77 |
| ▸ | TLK2 | Q86UE8 | 6/20 | 0.77 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 4/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955194 | 1.00 | PDPK1 (0.77) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL6970890 | 0.88 | PDPK1 (0.74) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL6970897 | 0.88 | PDPK1 (0.74) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL5728024 | 0.87 | TLK2 (1.00) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL5728025 | 0.87 | TLK2 (1.00) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL6963476 | 0.85 | PDPK1 (0.76) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL6957025 | 0.85 | PDPK1 (0.76) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL6957030 | 0.85 | PDPK1 (0.76) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL6963470 | 0.85 | PDPK1 (0.76) | PDPK1TLK2RETCHEK1FLT3 | |
| SCHEMBL6970563 | 0.82 | PDPK1 (0.69) | PDPK1TLK2RETCHEK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149092-B1 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | claimed |
| US-6313310-B1 | JUN N-TERMINAL KINASE (JNK) ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS; RHEUMATIC ARTHRITIS AND NEURO-DEGENERATIVE DISEASE TREATMENT | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | claimed |
| EP-1149092-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | claimed |
| WO-2000035906-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | claimed |
| EP-1149092-B1 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6313310-B1 | JUN N-TERMINAL KINASE (JNK) ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS; RHEUMATIC ARTHRITIS AND NEURO-DEGENERATIVE DISEASE TREATMENT | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | disclosed |
| EP-1149092-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000035906-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |