Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957080 | 0.94 | EDNRB (0.49) | EDNRBEDNRA | |
| SCHEMBL6640307 | 0.90 | EDNRA (0.48) | EDNRBEDNRA | |
| SCHEMBL6639043 | 0.87 | EDNRA (0.54) | EDNRBEDNRA | |
| SCHEMBL6644923 | 0.87 | EDNRA (0.46) | EDNRBEDNRA | |
| SCHEMBL6644381 | 0.84 | EDNRA (0.62) | EDNRBEDNRA | |
| SCHEMBL6644378 | 0.84 | EDNRA (0.62) | EDNRBEDNRA | |
| SCHEMBL6645856 | 0.84 | EDNRA (0.62) | EDNRBEDNRA | |
| SCHEMBL6644386 | 0.83 | EDNRA (0.51) | EDNRBEDNRA | |
| SCHEMBL6643555 | 0.83 | EDNRB (0.54) | EDNRBEDNRA | |
| SCHEMBL6968725 | 0.81 | EDNRA (0.47) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702012-B1 | Substituted isoxazole sulfonamides and their use as endothelin antagonists | BRISTOL MYERS SQUIBB CO (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-0702012-A1 | Substituted isoxazole sulfonamides and their use as endothelin antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-03-20 | — | — | EP | disclosed |