Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.71 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.64 |
| ▸ | TUBB | P07437 | 1/20 | 0.64 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.64 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.64 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.64 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.64 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.64 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.64 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.64 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.64 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.64 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.64 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.64 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.64 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.63 |
| ▸ | CNR2 | P34972 | 1/20 | 0.63 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973749 | 0.97 | ESR1 (0.68) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL6980679 | 0.95 | ESR1 (0.71) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11552962 | 0.93 | ESR1 (0.72) | ESR1ESR2CNR1 | |
| SCHEMBL7970907 | 0.92 | ESR1 (0.73) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL16380497 | 0.91 | ESR1 (0.67) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL11547336 | 0.91 | ESR1 (0.61) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7671512 | 0.91 | ESR1 (0.69) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7665777 | 0.91 | ESR1 (0.69) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL6425122 | 0.91 | ESR1 (0.68) | ESR1ESR2TUBB4ATUBBTUBA3C | |
| SCHEMBL7667665 | 0.90 | ESR1 (0.68) | ESR1ESR2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766559-B1 | CANNABINOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2003-11-19 | — | — | EP | disclosed |
| EP-0832888-B1 | Benzothiophene compounds, compositions, and methods | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |
| US-5981570-A | INHIBITING BONE LOSS OR BONE RESORPTION, PARTICULARLY OSTEOPOROSIS, CARDIOVASCULAR-RELATED PATHOLOGICAL CONDITIONS, INCLUDING HYPERLIPIDEMIA. | ELI LILLY AND COMPANY (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0766559-A4 | CANNABINOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-08-06 | — | — | EP | disclosed |
| EP-0766559-A1 | CANNABINOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-04-09 | — | — | EP | disclosed |
| US-5596106-A | ARYL-BENZO(B)THIOPHENE OR BENZO(B)FURAN COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-01-21 | — | — | US | disclosed |
| WO-1996002248-A1 | CANNABINOID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-02-01 | — | — | WO | disclosed |