Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12657390 | 0.88 | USP2 (0.42) | USP2ALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL10088520 | 0.85 | USP2 (0.47) | USP2ALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL18067936 | 0.81 | USP2 (0.41) | USP2ALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL18067928 | 0.81 | USP2 (0.34) | USP2ALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL89027 | 0.78 | USP2 (0.42) | USP2ALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL3253007 | 0.78 | — | — | |
| SCHEMBL14546650 | 0.76 | — | — | |
| SCHEMBL2225197 | 0.76 | — | — | |
| SCHEMBL89700 | 0.76 | USP2 (0.41) | USP2ALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL15674985 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0954521-B1 | 4- (THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO MCNEIL PHARM INC (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0954521-A1 | 4- (THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING ALPHA2-ADRENOCEPTOR AGONISTIC ACTIVITY | Ortho-McNeil Pharmaceutical, Inc. (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5750720-A | ALPHA-ADRENORECEPTORS AND CENTRAL NERVOUS SYSTEMS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| WO-1997035858-A1 | 4-[(THIEN-3-YL)METHYL] IMIDAZOLE DERIVATIVES HAVING α2-ADRENOCEPTOR AGONISTIC ACTIVITY | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-10-02 | — | — | WO | disclosed |
| EP-0002304-B1 | METHOD OF PREPARING A 3-IODOTHIOPHENE | Océ-Andeno B.V. (NL) | 1982-09-29 | — | — | EP | disclosed |
| US-4169839-A | REACTING 3-BROMOTHIOPHENE COMPOUND WITH COPPER IODIDE IN APROTIC SOLVENT | OCE-ANDENO B.V. (NL) | 1979-10-02 | — | — | US | disclosed |
| EP-0002304-A1 | Method of preparing a 3-iodothiophene | Océ-Andeno B.V. (NL) | 1979-06-13 | — | — | EP | disclosed |