Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.78 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.72 |
| ▸ | CDK1 | P06493 | 1/20 | 0.72 |
| ▸ | CDK2 | P24941 | 1/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11861276 | 0.88 | KDR (0.60) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL29819445 | 0.88 | KDR (1.00) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL6968182 | 0.88 | KDR (1.00) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7089495 | 0.85 | KDR (0.78) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL6958584 | 0.85 | KDR (0.78) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7002715 | 0.85 | KDR (0.78) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL11865835 | 0.85 | KDR (0.78) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7701869 | 0.85 | KDR (0.78) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7000053 | 0.85 | CHEK1 (0.97) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL6970245 | 0.85 | KDR (0.72) | KDRCHEK1CDK1CDK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023063-B1 | INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES | ABBOTT GMBH & CO KG (DE) | 2003-09-10 | — | — | EP | disclosed |
| US-6451834-B1 | Indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole derivatives | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-17 | — | — | US | disclosed |
| EP-1023063-A1 | INDENO 1,2-c]-, NAPHTHO 1,2-c]- AND BENZO 6,7]CYCLOHEPTA 1,2-c]PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999017769-A1 | INDENO[1,2-c]-, NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1999-04-15 | — | — | WO | disclosed |
| US-3932430-A | Substituted indeno, naphtho and cyclohepta pyrazoles | SANDOZ, INC. (US) | 1976-01-13 | — | — | US | disclosed |