Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.55 |
| ▸ | PDE4A | P27815 | 7/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7798499 | 0.93 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7800579 | 0.93 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7798537 | 0.93 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7802017 | 0.92 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7793017 | 0.91 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7800569 | 0.91 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7798408 | 0.91 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7792918 | 0.91 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7801809 | 0.90 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL7798761 | 0.89 | PDE4A (0.54) | PDE4BPDE4DPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| EP-0723962-B1 | Arylalkyl-thiadiazinones | MERCK PATENT GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| US-6025354-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-15 | — | — | US | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| US-5747489-A | Arylalkyl-thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |
| EP-0723962-A1 | Arylalkyl-thiadiazinones | MERCK PATENT GmbH (DE) | 1996-07-31 | — | — | EP | disclosed |