Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 16/20 | 0.54 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.54 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.54 |
| ▸ | PREP | P48147 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5480695 | 1.00 | DPP4 (0.54) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL2679489 | 1.00 | DPP4 (0.54) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL26094394 | 0.94 | DPP4 (0.59) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL858699 | 0.94 | DPP4 (0.59) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL5314581 | 0.94 | DPP4 (0.59) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL14834279 | 0.85 | — | — | |
| SCHEMBL16054584 | 0.85 | — | — | |
| SCHEMBL11820231 | 0.82 | CHRM2 (0.57) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL11451025 | 0.81 | CHRM2 (0.55) | DPP4DPP8DPP9DPP7PREP | |
| SCHEMBL185999 | 0.80 | CHRM2 (0.39) | DPP4DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1060178-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999045006-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 1999-09-10 | — | — | WO | disclosed |