Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.48 |
| ▸ | MME | P08473 | 9/20 | 0.48 |
| ▸ | CPA1 | P15085 | 2/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870584 | 0.83 | PPARG (0.44) | CYP2C19ALDH1A1POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL4446711 | 0.81 | EPHX1 (0.56) | ACECYP2C19ALDH1A1POLBCYP2C9 | |
| SCHEMBL5870326 | 0.81 | EPHX1 (0.56) | ACECYP2C19ALDH1A1POLBCYP2C9 | |
| SCHEMBL5870328 | 0.81 | EPHX1 (0.56) | ACECYP2C19ALDH1A1POLBCYP2C9 | |
| SCHEMBL7050743 | 0.74 | POLB (0.51) | CYP2C19ALDH1A1POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL1855157 | 0.72 | CYP1A2 (0.53) | CPA1CYP2C19ALDH1A1POLBCYP2C9 | |
| SCHEMBL11770018 | 0.71 | CYP2C19 (0.50) | CYP2C19ALDH1A1POLBCYP2C9SMN1; SMN2 | |
| SCHEMBL5172068 | 0.71 | MME (0.56) | ACEMMECPA1ACE2ALDH1A1 | |
| SCHEMBL7540831 | 0.70 | CYP2C19 (0.63) | CPA1CYP2C19ALDH1A1POLBCYP2C9 | |
| SCHEMBL6991601 | 0.70 | EPHX1 (0.53) | CYP2C19ALDH1A1POLBCYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358174-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002057248-A2 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |