⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL7203461 | 0.64 | — | — | |
| SCHEMBL10504177 | 0.62 | — | — | |
| SCHEMBL10888769 | 0.61 | — | — | |
| SCHEMBL6420159 | 0.59 | — | — | |
| SCHEMBL22169964 | 0.57 | ATM (0.32) | — | |
| SCHEMBL9373405 | 0.57 | — | — | |
| SCHEMBL10463799 | 0.56 | — | — | |
| SCHEMBL11183086 | 0.56 | — | — | |
| SCHEMBL4994523 | 0.55 | — | — | |
| SCHEMBL7362965 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911331-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-0694546-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and use | SEARLE & CO (US) | 2001-06-06 | — | — | EP | disclosed |
| EP-0694545-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2000-07-26 | — | — | EP | disclosed |
| EP-0583421-B1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SEARLE & CO (US) | 1999-06-16 | — | — | EP | disclosed |
| EP-0911331-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1999-04-28 | — | — | EP | disclosed |
| EP-0512400-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 1998-12-02 | — | — | EP | disclosed |
| US-5661146-A | ANALGESICS | G.D. SEARLE & CO. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5576315-A | Substituted dibenzoxazepine compounds and methods for treating osteoporosis and ischemia | G.D. SEARLE & CO. (US) | 1996-11-19 | — | — | US | disclosed |
| US-5512561-A | ANALGESICS, PROSTAGLANDIN ANTAGONIST | G. D. SEARLE & CO. (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0703908-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5180720-A | Prostaglandin E2 antagonists | G. D. SEARLE & CO. (US) | 1993-01-19 | — | — | US | disclosed |
| EP-0512399-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |
| EP-0512400-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |
| US-3992375-A | Dibenzoxazepine N-carboxylic acid hydrazines and derivatives | G. D. SEARLE & CO. (US) | 1976-11-16 | — | — | US | disclosed |
| US-3992375-A | Dibenzoxazepine N-carboxylic acid hydrazines and derivatives | G. D. SEARLE & CO. (US) | 1976-11-16 | — | — | US | disclosed |
| US-3989719-A | Dibenzoxazepine N-carboxylic acid hydrazides and derivatives | G. D. SEARLE & CO. (US) | 1976-11-02 | — | — | US | disclosed |
| US-3989719-A | Dibenzoxazepine N-carboxylic acid hydrazides and derivatives | G. D. SEARLE & CO. (US) | 1976-11-02 | — | — | US | disclosed |
| US-3989719-A | Dibenzoxazepine N-carboxylic acid hydrazides and derivatives | G. D. SEARLE & CO. (US) | 1976-11-02 | — | — | US | disclosed |
| US-3917649-A | Dibenzoxazepine N-carboxylic acid hydrazides and derivatives | G.D. SEARLE AND CO., 1751 LAKE COOK RD., DEERFIELD, IL 60015 A CORP. OF DE | 1975-11-04 | — | — | US | disclosed |
| US-3917649-A | Dibenzoxazepine N-carboxylic acid hydrazides and derivatives | G.D. SEARLE AND CO., 1751 LAKE COOK RD., DEERFIELD, IL 60015 A CORP. OF DE | 1975-11-04 | — | — | US | disclosed |