SCHEMBL6970402

SCHEMBL6970402

C=C[C@H]1CN(CCCCCCC)CC[C@H]1CC[C@@H](NC(N)=O)c1ccnc2ccc(OC)cc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR8 P51685 1/20 0.47
CYP3A4 P08684 3/20 0.46
LMNA P02545 1/20 0.46
CYP2D6 P10635 4/20 0.45
KCNH2 Q12809 4/20 0.45
SLC22A1 O15245 3/20 0.45
ABCB11 O95342 3/20 0.45
ABCB1 P08183 3/20 0.45
ADRA2A P08913 3/20 0.45
SLC6A4 P31645 3/20 0.45
OPRM1 P35372 3/20 0.45
SCN1A P35498 3/20 0.45
SCN2A Q99250 3/20 0.45
SCN3A Q9NY46 3/20 0.45
ALDH1A1 P00352 2/20 0.45
HSD17B10 Q99714 2/20 0.45
SLC22A2 O15244 2/20 0.45
KDM4E B2RXH2 2/20 0.45
THRB P10828 1/20 0.45
MEN1 O00255 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6970395 1.00 CCR8 (0.47) CCR8CYP3A4LMNACYP2D6KCNH2
SCHEMBL6977808 0.94 CYP3A4 (0.48) CCR8CYP3A4LMNACYP2D6KCNH2
SCHEMBL6979152 0.94 CYP3A4 (0.48) CCR8CYP3A4LMNACYP2D6KCNH2
SCHEMBL6976924 0.88 CCR8 (0.48) CCR8CYP3A4LMNACYP2D6KCNH2
SCHEMBL6976922 0.88 CCR8 (0.48) CCR8CYP3A4LMNACYP2D6KCNH2
SCHEMBL6972265 0.88 KCNH2 (0.53) CYP3A4CYP2D6KCNH2SLC22A1ABCB11
SCHEMBL6972259 0.88 KCNH2 (0.53) CYP3A4CYP2D6KCNH2SLC22A1ABCB11
SCHEMBL7082023 0.84 CYP2D6 (0.52) CCR8CYP3A4LMNACYP2D6KCNH2
SCHEMBL6968777 0.84 CYP2D6 (0.52) CCR8CYP3A4LMNACYP2D6KCNH2
SCHEMBL7082020 0.84 CYP2D6 (0.52) CCR8CYP3A4LMNACYP2D6KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051413-B1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2003-06-04 EP claimed
EP-1051413-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2000-11-15 EP claimed
WO-1999037635-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 1999-07-29 WO claimed
EP-1051413-B1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2003-06-04 EP disclosed
EP-1051413-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2000-11-15 EP disclosed
WO-1999037635-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 1999-07-29 WO disclosed