Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 5/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769747 | 0.86 | BRD4 (0.40) | BRD4TSHRGAAKMT2AALDH1A1 | |
| SCHEMBL16512555 | 0.82 | TSHR (0.40) | BRD4TSHRGAAHSD17B10MGAM | |
| SCHEMBL16512742 | 0.82 | TSHR (0.40) | BRD4TSHRGAAHSD17B10MGAM | |
| SCHEMBL14363249 | 0.78 | MGAM (0.44) | TSHRGAAHSD17B10MGAMSI | |
| SCHEMBL24197361 | 0.78 | BRD4 (0.50) | BRD4TSHRGAAHSD17B10MGAM | |
| SCHEMBL2036054 | 0.78 | — | — | |
| SCHEMBL24289838 | 0.78 | BRD4 (0.37) | BRD4TSHRNR1H2 | |
| SCHEMBL6971253 | 0.77 | — | — | |
| SCHEMBL868953 | 0.74 | BRD4 (0.47) | BRD4TSHRKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL3631878 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275241-A1 | Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof | USV LIMITED (IN) | 2008-11-06 | — | — | US | disclosed |
| US-20070112030-A1 | Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto | MERCK & CO., INC. | 2007-05-17 | — | — | US | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112030-A1 | Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto | GRM1, GRM3, GRM2 | BRD4 411/4885TSHR 2978/4885GAA 4233/4885 |
| US-20080275241-A1 | Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof | CYP4A11, CYP3A43, VKORC1 | BRD4 3815/4885TSHR 4462/4885GAA 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.