Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 1.00 |
| ▸ | CCNE1 | P24864 | 19/20 | 0.47 |
| ▸ | CDK2 | P24941 | 19/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 17/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971308 | 1.00 | MAPK8 (1.00) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL14040855 | 0.98 | MAPK8 (0.96) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL13198013 | 0.90 | MAPK8 (0.81) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL6958386 | 0.88 | MAPK8 (0.78) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL6958391 | 0.88 | MAPK8 (0.78) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL6965314 | 0.87 | MAPK8 (0.77) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL6965328 | 0.87 | MAPK8 (0.77) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL13207561 | 0.87 | MAPK8 (0.76) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL6969422 | 0.86 | MAPK8 (0.75) | MAPK8CCNE1CDK2CCNE2 | |
| SCHEMBL6968404 | 0.86 | MAPK8 (0.75) | MAPK8CCNE1CDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149092-B1 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6313310-B1 | JUN N-TERMINAL KINASE (JNK) ENZYME INHIBITORS; ANTIINFLAMMATORY AGENTS; RHEUMATIC ARTHRITIS AND NEURO-DEGENERATIVE DISEASE TREATMENT | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | disclosed |
| EP-1149092-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000035906-A2 | 4- AND 5-ALKYNYLOXINDOLES AND 4- AND 5-ALKENYLOXINDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |