Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 7/20 | 0.59 |
| ▸ | F10 | P00742 | 9/20 | 0.56 |
| ▸ | PLAU | P00749 | 2/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | HPN | P05981 | 2/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.53 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350464 | 1.00 | F2 (0.59) | F2F10PLAUPLGHPN | |
| SCHEMBL7309132 | 0.92 | F2 (0.58) | F2F10PLAUPLGHPN | |
| SCHEMBL7342625 | 0.91 | F2 (0.66) | F2F10 | |
| SCHEMBL7335469 | 0.91 | F2 (0.66) | F2F10 | |
| SCHEMBL7342607 | 0.91 | F2 (0.66) | F2F10 | |
| SCHEMBL7339840 | 0.90 | F2 (0.58) | F2 | |
| SCHEMBL7350482 | 0.89 | F2 (0.57) | F2F10 | |
| SCHEMBL6971414 | 0.89 | F2 (0.57) | F2F10 | |
| SCHEMBL7341625 | 0.89 | F2 (0.59) | F2 | |
| SCHEMBL7340271 | 0.89 | F2 (0.59) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | claimed |
| EP-0934064-B1 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-0858262-B1 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-0949921-B1 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-0820287-B1 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-03-27 | — | — | EP | disclosed |
| US-6133297-A | 4-((SUBSTITUTED)AMINO(SUBSTITUTED)ALKYLCARBONYLAMINO (SUBTITUTED)ALKYLAMINO)PYRIDINE COMPOUNDS OF GIVEN FORMULA; ADMINISTERING TO TREAT THROMBOSIS | MERCK & CO., INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-6087373-A | A SERINE PROTEASE INHIBITOR FOR PREVENTING OR TREATING UNSTABLE ANGINA, REFRACTORY ANGINA, MYOCARDIAL INFARCTION, TRANSIENT ISCHEMIC ATTACKS, ATRIAL FIBRILLATION, THROMBOTIC STROKE, EMBOLIC STROKE, DEEP VEIN THROMBOSIS | MERCK & CO., INC. (US) | 2000-07-11 | — | — | US | disclosed |
| US-6017934-A | Thrombin inhibitors | MERCK & CO., INC. (US) | 2000-01-25 | — | — | US | disclosed |
| US-6004976-A | ADMINISTERING IMIDAZO(4,5-C)PYRIDIN-2,4-DIONE DERIVATIVES AS ANTICOAGULANTS | MERCK & CO., INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0949921-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 1999-10-20 | — | — | EP | disclosed |
| EP-0949921-A4 | — | — | 1999-10-20 | — | — | EP | disclosed |
| WO-1998006396-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1998-02-19 | — | — | WO | disclosed |
| US-5629324-A | ANTICOAGULANTS | MERCK & CO., INC. (US) | 1997-05-13 | — | — | US | disclosed |
| WO-1996031504-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1996-10-10 | — | — | WO | disclosed |