Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963063 | 0.81 | CYP3A4 (0.35) | ALDH1A1KMT2A | |
| SCHEMBL6962344 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1POLB | |
| SCHEMBL6968027 | 0.80 | PARP1 (0.35) | KDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL6961205 | 0.79 | PARP1 (0.39) | KMT2A | |
| SCHEMBL6966047 | 0.78 | ESR1 (0.37) | KMT2A | |
| SCHEMBL6974425 | 0.77 | GBA1 (0.39) | KDM4EALDH1A1KMT2APOLB | |
| SCHEMBL6962637 | 0.77 | GAA (0.39) | ALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL6969257 | 0.77 | SMN1; SMN2 (0.39) | KDM4EALDH1A1KMT2ALMNAPOLB | |
| SCHEMBL6967680 | 0.76 | KMT2A (0.38) | KDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL6970691 | 0.76 | KDM4E (0.32) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |