Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204107 | 0.95 | NPC1 (0.46) | NPC1HRH2HRH1UCHL1FKBP1A | |
| SCHEMBL564404 | 0.95 | NPC1 (0.46) | NPC1HRH2HRH1UCHL1FKBP1A | |
| SCHEMBL2706083 | 0.90 | NPC1 (0.52) | NPC1HRH2HRH1UCHL1EPHX2 | |
| SCHEMBL203942 | 0.90 | NPC1 (0.52) | NPC1HRH2HRH1UCHL1EPHX2 | |
| SCHEMBL15481363 | 0.87 | NPC1 (0.41) | NPC1HRH2HRH1UCHL1FKBP1A | |
| SCHEMBL18213987 | 0.85 | NPC1 (0.60) | NPC1HRH2HRH1UCHL1EPHX2 | |
| SCHEMBL18209654 | 0.85 | NPC1 (0.60) | NPC1HRH2HRH1UCHL1EPHX2 | |
| SCHEMBL4955279 | 0.85 | KLK7 (0.53) | NPC1UCHL1FKBP1AEPHX2MEN1 | |
| SCHEMBL15848456 | 0.85 | KLK7 (0.53) | NPC1UCHL1FKBP1AEPHX2MEN1 | |
| SCHEMBL15848455 | 0.85 | KLK7 (0.53) | NPC1UCHL1FKBP1AEPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421855-A1 | DIARYL ETHERS | Tibotec Pharmaceuticals (IE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122162-A1 | DIARYL ETHERS | TIBOTEC PHARMACEUTICALS (IE) | 2010-10-28 | — | — | WO | disclosed |