Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.46 |
| ▸ | KDR | P35968 | 13/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | YES1 | P07947 | 2/20 | 0.42 |
| ▸ | CSK | P41240 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3192319 | 0.84 | SRC (0.53) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3205210 | 0.83 | EGFR (0.53) | SRCKDREGFRLCKYES1 | |
| SCHEMBL6970862 | 0.80 | SRC (0.47) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3274564 | 0.80 | SRC (0.47) | SRCKDREGFRLCKYES1 | |
| SCHEMBL4022457 | 0.79 | SRC (0.68) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3283169 | 0.78 | SRC (0.64) | SRCKDREGFRLCKYES1 | |
| SCHEMBL6613274 | 0.78 | EGFR (0.70) | SRCKDREGFR | |
| SCHEMBL3274956 | 0.77 | SRC (0.64) | SRCKDREGFRLCKYES1 | |
| SCHEMBL3275626 | 0.77 | SRC (0.68) | SRCKDREGFRLCKYES1 | |
| SCHEMBL1012776 | 0.77 | EGFR (0.62) | SRCKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001094341-A9 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2003-04-17 | — | — | WO | disclosed |
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |