Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.40 |
| ▸ | PDE4A | P27815 | 11/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678430 | 0.97 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6678661 | 0.93 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6680575 | 0.92 | PDE4D (0.41) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6677634 | 0.91 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6675568 | 0.90 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6675950 | 0.90 | PDE4D (0.41) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6676273 | 0.90 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6680280 | 0.90 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6678304 | 0.89 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4CPDE3B | |
| SCHEMBL6837633 | 0.88 | SMN1; SMN2 (0.45) | PDE4DPDE4BPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |