Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28845828 | 0.90 | TDP1 (0.66) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL14722524 | 0.87 | TDP1 (0.66) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL6442808 | 0.83 | TDP1 (1.00) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL13233290 | 0.83 | TDP1 (0.70) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL38662718 | 0.82 | TDP1 (0.63) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL14851019 | 0.80 | TDP1 (0.78) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL8653839 | 0.80 | TDP1 (0.66) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL9814242 | 0.80 | TDP1 (0.84) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL30294105 | 0.80 | TDP1 (0.84) | TDP1LMNASMN1; SMN2HTTTSHR | |
| SCHEMBL3161153 | 0.80 | TDP1 (0.84) | TDP1LMNASMN1; SMN2HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |