SCHEMBL6973504

SCHEMBL6973504

O=C1NC(CCc2ccc(O)cc2)C(=O)S1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
CA2 P00918 1/20 0.37
KDM4E B2RXH2 2/20 0.37
F13A1 P00488 1/20 0.37
SLC6A2 P23975 2/20 0.36
TAAR1 Q96RJ0 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36
CYP2C19 P33261 1/20 0.36
HTR3A P46098 1/20 0.36
BACE1 P56817 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GAA P10253 1/20 0.36
CA3 P07451 1/20 0.36
CAPN1 P07384 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
BLM P54132 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8888904 0.91 ESR1 (0.38) ESR1ESR2CA2KDM4EF13A1
SCHEMBL8887977 0.89 ESR1 (0.40) ESR1ESR2KDM4ESLC6A2ALDH1A1
SCHEMBL8890490 0.88 ESR1 (0.42) ESR1ESR2KDM4ESLC6A2ALDH1A1
SCHEMBL1745276 0.83 CAPN1 (0.45) ESR1ESR2ADRA2AGAACAPN1
SCHEMBL7632885 0.73 CXCR4 (0.38) ADRA2AGAACAPN1
SCHEMBL28607425 0.72 CXCR4 (0.46) ESR1ESR2CA2KDM4ESLC6A2
SCHEMBL8888947 0.71 ESR1 (0.41) ESR1ESR2CA2KDM4EF13A1
SCHEMBL6964722 0.69 POLB (0.41) KDM4EL3MBTL1LMNA
SCHEMBL6973500 0.69 MAPT (0.51) ESR1ESR2KDM4ESLC6A2TAAR1
SCHEMBL6960177 0.68 POLB (0.40) KDM4EL3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0783496-B9 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-09-03 EP disclosed
EP-0783496-B1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-26 EP disclosed
US-5965589-A AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-12 US disclosed
EP-0783496-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-16 EP disclosed
WO-1997000249-A1 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-01-03 WO disclosed
WO-1996005186-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-02-22 WO disclosed