Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 7/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089543 | 0.85 | PIM1 (0.70) | PIM1HPGDPIM2AKR1B1NPC1 | |
| SCHEMBL13846586 | 0.85 | PIM1 (0.70) | PIM1HPGDPIM2AKR1B1NPC1 | |
| SCHEMBL2546776 | 0.84 | PIM1 (0.69) | PIM1HPGDPIM2AKR1B1NPC1 | |
| SCHEMBL6973632 | 0.84 | CSNK2A2 (0.49) | PIM1HPGDPIM2AKR1B1NPC1 | |
| SCHEMBL8187521 | 0.82 | PIM1 (0.70) | PIM1HPGDPIM2AKR1B1NPC1 | |
| SCHEMBL8181336 | 0.81 | PIM1 (0.53) | PIM1HPGDPIM2AKR1B1NPC1 | |
| SCHEMBL6972871 | 0.80 | PDE4B (0.58) | PIM1HPGDPIM2MEN1MAPT | |
| SCHEMBL6972866 | 0.80 | PDE4B (0.58) | PIM1HPGDPIM2MEN1MAPT | |
| SCHEMBL14381413 | 0.80 | PIM1 (0.55) | PIM1HPGDPIM2AKR1B1NPC1 | |
| SCHEMBL13846678 | 0.78 | PIM1 (0.67) | PIM1HPGDPIM2AKR1B1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783496-B9 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-0783496-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| WO-1997000249-A1 | HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-03 | — | — | WO | disclosed |