Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082887 | 0.96 | GCGR (0.33) | GCGRTLR7HDAC1HDAC8 | |
| SCHEMBL6965442 | 0.95 | GCGR (0.36) | GCGRTLR7TP53 | |
| SCHEMBL6974517 | 0.93 | MEN1 (0.36) | GCGR | |
| SCHEMBL6974433 | 0.90 | GCGR (0.37) | GCGR | |
| SCHEMBL6966194 | 0.90 | GCGR (0.34) | GCGR | |
| SCHEMBL6962650 | 0.88 | TLR7 (0.35) | GCGRTLR7HDAC1HDAC8TP53 | |
| SCHEMBL6974422 | 0.88 | GCGR (0.31) | GCGR | |
| SCHEMBL7084484 | 0.88 | HSP90B1 (0.37) | GCGRTLR7HDAC1HDAC8TP53 | |
| SCHEMBL6975444 | 0.87 | — | — | |
| SCHEMBL6963837 | 0.86 | MEN1 (0.37) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |