Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90B1 | P14625 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 5/20 | 0.35 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7080973 | 0.96 | HSP90B1 (0.38) | HSP90B1ALDH1A1LMNAMAPTGCGR | |
| SCHEMBL7079137 | 0.94 | HSP90B1 (0.41) | HSP90B1ALDH1A1LMNAMAPTGCGR | |
| SCHEMBL6961258 | 0.93 | HSP90B1 (0.34) | HSP90B1ALDH1A1MAPTGCGRTRAP1 | |
| SCHEMBL6966836 | 0.91 | HSP90B1 (0.43) | HSP90B1ALDH1A1LMNAMAPTGCGR | |
| SCHEMBL6967398 | 0.91 | HSP90B1 (0.33) | HSP90B1TRAP1HSP90AA1HSP90AB1KMT2A | |
| SCHEMBL7084484 | 0.90 | HSP90B1 (0.37) | HSP90B1ALDH1A1LMNAMAPTGCGR | |
| SCHEMBL8100876 | 0.89 | HSP90B1 (0.43) | HSP90B1ALDH1A1LMNAMAPTGCGR | |
| SCHEMBL7084131 | 0.89 | TLR8 (0.35) | HSP90B1ALDH1A1LMNAMAPTGCGR | |
| SCHEMBL6961520 | 0.89 | HSP90B1 (0.32) | HSP90B1GCGRTRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL6976885 | 0.88 | MEN1 (0.33) | HSP90B1ALDH1A1LMNAMAPTGCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |