Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 13/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RARG | P13631 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967584 | 0.93 | MEN1 (0.49) | MEN1MAPTKMT2ATDP1PPARG | |
| SCHEMBL6975391 | 0.91 | MEN1 (0.49) | MEN1MAPTKMT2ATDP1PPARG | |
| SCHEMBL10635803 | 0.88 | MEN1 (0.54) | MEN1MAPTKMT2ATDP1PPARG | |
| SCHEMBL6977206 | 0.88 | PPARG (0.46) | MEN1MAPTKMT2ATDP1PPARG | |
| SCHEMBL10641976 | 0.88 | MAPT (0.53) | MEN1MAPTKMT2ATDP1PPARG | |
| Troglitazone SCHEMBL21630 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1PPARG | |
| Troglitazone SCHEMBL15888838 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1PPARG | |
| Troglitazone SCHEMBL5672813 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1PPARG | |
| Troglitazone SCHEMBL1536757 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1PPARG | |
| Troglitazone SCHEMBL8496660 | 0.88 | MEN1 (0.64) | MEN1MAPTKMT2ATDP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |