Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | RORC | P51449 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | WDR5 | P61964 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.58 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.58 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.58 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674600 | 0.84 | KMT2A (0.56) | KMT2AMAPTRORCWDR5MEN1 | |
| SCHEMBL6396133 | 0.83 | KMT2A (0.85) | KMT2AMAPTGAAWDR5MEN1 | |
| SCHEMBL6780418 | 0.83 | MAPT (0.61) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL19174351 | 0.82 | HDAC2 (0.76) | KMT2AMAPTRORCGAAWDR5 | |
| SCHEMBL9445656 | 0.81 | SMN1; SMN2 (0.63) | KMT2ARORCGAAHTTSMN1; SMN2 | |
| SCHEMBL402139 | 0.81 | MAPT (0.77) | KMT2AMAPTRORCGAAWDR5 | |
| SCHEMBL1548208 | 0.81 | KMT2A (0.68) | KMT2AMAPTGAAMEN1NPC1 | |
| SCHEMBL31399753 | 0.81 | KMT2A (0.62) | KMT2AMAPTGAAWDR5MEN1 | |
| SCHEMBL1456274 | 0.81 | KMT2A (0.74) | KMT2AMAPTRORCGAAWDR5 | |
| SCHEMBL1842636 | 0.81 | KMT2A (0.62) | KMT2AMAPTGAAWDR5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |