SCHEMBL6975385

SCHEMBL6975385

CC(C)(C)OC(=O)N=NC(=O)OC(C)(C)C.COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OCCCN4CCOCC4)c23)c1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRC P12931 20/20 0.77
KDR P35968 15/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6975381 1.00 SRC (0.77) SRCKDR
SCHEMBL3192521 0.90 SRC (0.95) SRCKDR
SCHEMBL3282493 0.88 SRC (1.00) SRCKDR
SCHEMBL3281905 0.85 SRC (1.00) SRCKDR
SCHEMBL3276140 0.84 SRC (0.86) SRCKDR
SCHEMBL3283205 0.83 SRC (0.84) SRCKDR
SCHEMBL3200998 0.82 SRC (1.00) SRCKDR
SCHEMBL3740944 0.81 SRC (0.83) SRCKDR
SCHEMBL3196301 0.80 SRC (1.00) SRCKDR
SCHEMBL3195124 0.78 SRC (1.00) SRCKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001094341-A9 QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS ASTRAZENECA AB (SE) 2003-04-17 WO disclosed
EP-1292594-A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS AstraZeneca AB (SE) 2003-03-19 EP disclosed
WO-2001094341-A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS ASTRAZENECA AB (SE) 2001-12-13 WO disclosed