Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 16/20 | 0.61 |
| ▸ | HTR2B | P41595 | 14/20 | 0.61 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018076 | 1.00 | HTR2C (0.61) | HTR2CHTR2BHTR6HTR2AHTR3E | |
| SCHEMBL2019818 | 0.91 | HTR2C (0.54) | HTR2CHTR2BHTR6HTR2A | |
| SCHEMBL2017216 | 0.90 | HTR2C (0.65) | HTR2CHTR2BHTR6HTR2AHTR3E | |
| SCHEMBL2018056 | 0.88 | HTR2C (0.51) | HTR2CHTR2BHTR6HTR2AHTR3A | |
| SCHEMBL3627752 | 0.84 | HTR2C (0.57) | HTR2CHTR2BHTR6HTR2A | |
| SCHEMBL692581 | 0.84 | HTR2C (0.47) | HTR2CHTR2BHTR6HTR2A | |
| SCHEMBL2019564 | 0.84 | HTR2C (0.47) | HTR2CHTR2BHTR6HTR2A | |
| SCHEMBL2021572 | 0.84 | HTR2C (0.47) | HTR2CHTR2BHTR6HTR2A | |
| SCHEMBL2018378 | 0.81 | HTR2C (0.48) | HTR2CHTR2BHTR6HTR2A | |
| SCHEMBL2591154 | 0.81 | HTR2C (0.48) | HTR2CHTR2BHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | claimed |
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |