Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.69 |
| ▸ | IGF1R | P08069 | 12/20 | 0.66 |
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | BRD4 | O60885 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.57 |
| ▸ | FAM20C | Q8IXL6 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116462 | 0.85 | IGF1R (0.79) | EPHB4IGF1RKDRBRD4EGFR | |
| SCHEMBL6976835 | 0.84 | IGF1R (0.78) | EPHB4IGF1RKDRBRD4EGFR | |
| SCHEMBL6981394 | 0.83 | CLK1 (0.69) | EPHB4EGFRCDK2CLK2DYRK1A | |
| SCHEMBL1171685 | 0.82 | EPHB4 (0.71) | EPHB4IGF1RKDREGFRINSR | |
| SCHEMBL7010764 | 0.82 | PDE5A (0.59) | EPHB4LMNASLK | |
| SCHEMBL1172122 | 0.82 | EPHB4 (0.79) | EPHB4IGF1R | |
| SCHEMBL12864817 | 0.82 | EPHB4 (1.00) | EPHB4 | |
| SCHEMBL1171630 | 0.82 | EPHB4 (0.79) | EPHB4IGF1RPLK1 | |
| SCHEMBL6980742 | 0.80 | FAM20C (0.78) | IGF1RKDRBRD4EGFRINSR | |
| SCHEMBL6645968 | 0.80 | IGF1R (1.00) | EPHB4IGF1RKDRBRD4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |