Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.69 |
| ▸ | IGF1R | P08069 | 13/20 | 0.67 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | FAM20C | Q8IXL6 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976694 | 0.90 | EGFR (0.81) | EGFRIGF1RKDRINSRMET | |
| SCHEMBL6971010 | 0.86 | EGFR (0.74) | EGFRIGF1RKDRINSRMET | |
| Hydrochloric Acid SCHEMBL7945502 | 0.84 | EGFR (0.71) | EGFRIGF1RKDRINSRMET | |
| SCHEMBL1377802 | 0.83 | EGFR (1.00) | EGFRIGF1RKDRCDK2ROCK1 | |
| SCHEMBL1116424 | 0.82 | EGFR (0.83) | EGFRIGF1RKDRCDK2ROCK1 | |
| SCHEMBL7952306 | 0.81 | IGF1R (0.67) | EGFRIGF1RKDRINSRMET | |
| SCHEMBL1116426 | 0.81 | IGF1R (0.74) | EGFRIGF1RKDRINSRMET | |
| SCHEMBL7954371 | 0.81 | EGFR (0.64) | EGFRIGF1RKDRINSRMET | |
| SCHEMBL6981276 | 0.80 | IGF1R (1.00) | EGFRIGF1RKDRINSRMET | |
| SCHEMBL31046394 | 0.80 | EGFR (0.92) | EGFRIGF1RKDRCDK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |