Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.63 |
| ▸ | EGFR | P00533 | 14/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.63 |
| ▸ | FLT1 | P17948 | 10/20 | 0.63 |
| ▸ | FLT4 | P35916 | 9/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | KIF5B | P33176 | 2/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.57 |
| ▸ | TEK | Q02763 | 2/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.57 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | CIT | O14578 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.57 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5452360 | 0.95 | EGFR (0.68) | KDREGFRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL5465111 | 0.95 | EGFR (0.69) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5453241 | 0.95 | KDR (0.69) | KDREGFRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL5451307 | 0.94 | EGFR (0.70) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL6976247 | 0.93 | EGFR (0.66) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5448866 | 0.91 | KDR (0.73) | KDREGFRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL5453290 | 0.90 | KDR (0.71) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL14564684 | 0.88 | EGFR (0.74) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5755703 | 0.88 | EGFR (0.74) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5451248 | 0.88 | EGFR (0.72) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274692-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001077085-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-10-18 | — | — | WO | disclosed |