Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981298 | 0.91 | SLC6A4 (0.58) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL6984286 | 0.91 | SLC6A4 (0.51) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL8317286 | 0.82 | SLC6A4 (0.65) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL8315402 | 0.81 | SLC6A4 (0.68) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL8317283 | 0.79 | SLC6A4 (0.60) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL8312784 | 0.79 | SLC6A4 (0.60) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL6982122 | 0.78 | SLC6A4 (0.48) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL2877415 | 0.78 | SLC6A4 (0.58) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL6981094 | 0.78 | SLC6A4 (0.58) | KDM4ELMNAALOX15HTR2ASLC6A4 | |
| SCHEMBL6975000 | 0.78 | SLC6A4 (0.54) | KDM4ELMNAALOX15HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1131321-B1 | INDOLE DERIVATIVES AND THEIR USE AS SEROTONIN RECEPTOR LIGANDS | LILLY CO ELI (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6329366-B1 | HETEROCYCLIC, PIPERIDINE, INDOLE DERIVITIVES FOR TREATMENT OF NERVOUS SYSTEM DISORDERS AND SEROTONIN ANTAGONIST | ELI LILLY AND COMPANY LIMITED (GB) | 2001-12-11 | — | — | US | disclosed |