Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 1.00 |
| ▸ | KDR | P35968 | 9/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KIF5B | P33176 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3279937 | 0.99 | SRC (0.98) | SRCKDREGFRBRAFTNNI3K | |
| SCHEMBL3274759 | 0.87 | SRC (0.77) | SRCKDRBRAFRETKIF5B | |
| Hydrochloric Acid SCHEMBL3274525 | 0.86 | SRC (0.75) | SRCKDREGFRRETKIF5B | |
| Hydrochloric Acid SCHEMBL3277321 | 0.84 | SRC (0.73) | SRCKDREGFRBRAFTNNI3K | |
| SCHEMBL6912170 | 0.84 | TNNI3K (0.76) | SRCEGFRBRAFTNNI3K | |
| Hydrochloric Acid SCHEMBL12003627 | 0.83 | TNNI3K (0.75) | SRCEGFRBRAFTNNI3K | |
| Hydrochloric Acid SCHEMBL3276171 | 0.83 | SRC (0.70) | SRCKDREGFRALDH1A1HPGD | |
| SCHEMBL3198124 | 0.83 | SRC (1.00) | SRCKDREGFR | |
| SCHEMBL3280052 | 0.80 | SRC (0.67) | SRCKDREGFRBRAFRET | |
| SCHEMBL3282493 | 0.80 | SRC (1.00) | SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292594-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | AstraZeneca AB (SE) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001094341-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | WO | disclosed |