Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.66 |
| ▸ | RARG | P13631 | 1/20 | 0.61 |
| ▸ | RXRA | P19793 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966428 | 0.88 | PPARG (0.64) | PPARGRARGRXRAFFAR1PPARA | |
| SCHEMBL8797615 | 0.86 | PPARG (0.72) | PPARGRARGRXRAFFAR1PPARA | |
| SCHEMBL8458411 | 0.85 | PPARG (0.74) | PPARGRARGRXRAFFAR1TSHR | |
| SCHEMBL9120637 | 0.84 | PPARG (0.63) | PPARGRARGRXRAFFAR1PPARA | |
| SCHEMBL6978523 | 0.83 | PPARG (0.51) | PPARGRARGRXRAFFAR1 | |
| SCHEMBL6963699 | 0.83 | PPARG (0.60) | PPARGRARGRXRAFFAR1PPARA | |
| SCHEMBL6963701 | 0.83 | PPARG (0.60) | PPARGRARGRXRAFFAR1PPARA | |
| SCHEMBL1072226 | 0.83 | FFAR1 (0.77) | PPARGFFAR1TSHRPPARA | |
| SCHEMBL9121895 | 0.83 | PPARG (0.66) | PPARGRARGRXRAFFAR1PPARA | |
| SCHEMBL12515224 | 0.82 | FFAR1 (0.69) | PPARGRXRAFFAR1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | claimed |
| EP-0801063-B1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | REDDYS LAB LTD DR (IN) | 2003-01-15 | — | — | EP | disclosed |
| EP-0801063-A1 | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-10-15 | — | — | EP | disclosed |