Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.55 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977536 | 0.93 | MAPK14 (0.55) | MAPK14SMORAF1BRAF | |
| SCHEMBL6977319 | 0.90 | MAPK14 (0.64) | MAPK14RAF1BRAFMAPK13HSPB1 | |
| SCHEMBL6980077 | 0.84 | MAPK14 (0.55) | MAPK14SMO | |
| SCHEMBL6978720 | 0.83 | MAPK14 (0.63) | MAPK14RAF1BRAF | |
| SCHEMBL6978667 | 0.83 | MAPK14 (0.55) | MAPK14SMORAF1BRAFMAPK13 | |
| SCHEMBL7857295 | 0.80 | MAPK14 (0.65) | MAPK14RAF1BRAF | |
| SCHEMBL6974176 | 0.79 | MAPK14 (0.54) | MAPK14RAF1BRAFMAPK13MAPK12 | |
| SCHEMBL6970377 | 0.79 | MAPK14 (0.53) | MAPK14SMORAF1BRAFMAPK13 | |
| SCHEMBL6975392 | 0.77 | MAPK14 (0.53) | MAPK14SMORAF1BRAFMAPK13 | |
| SCHEMBL6979778 | 0.76 | MAPK14 (0.56) | MAPK14SMORAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | claimed |