Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.51 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.51 |
| ▸ | ULK1 | O75385 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 4/20 | 0.50 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716652 | 0.79 | EGFR (1.00) | EGFR | |
| SCHEMBL1707650 | 0.78 | EGFR (0.63) | EGFRPTK2ALKCDK19ULK1 | |
| SCHEMBL653918 | 0.76 | ZAP70 (0.68) | EGFRPTK2ALKCDK19ULK1 | |
| SCHEMBL18808202 | 0.76 | EGFR (0.65) | EGFR | |
| SCHEMBL24728127 | 0.75 | SYK (0.62) | EGFRPTK2ALKULK1IGF1R | |
| SCHEMBL1116484 | 0.75 | PTK2 (0.74) | EGFRPTK2ALKCDK19ULK1 | |
| SCHEMBL1707782 | 0.73 | ZAP70 (0.59) | EGFRPTK2ALKULK1IGF1R | |
| SCHEMBL17547549 | 0.73 | PTK2 (0.72) | EGFRPTK2ALKCDK19ULK1 | |
| SCHEMBL23764834 | 0.72 | MAPK8 (0.71) | PTK2ALKCDK19ULK1IGF1R | |
| SCHEMBL23764833 | 0.72 | PTK2 (0.71) | EGFRPTK2ALKCDK19ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |