Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 15/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.63 |
| ▸ | LMNA | P02545 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 9/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.60 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HBB | P68871 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25179738 | 0.84 | NPSR1 (0.68) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2852620 | 0.83 | NPSR1 (0.67) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL19757194 | 0.81 | NPSR1 (0.65) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL8019990 | 0.81 | NPSR1 (0.64) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL25186625 | 0.80 | MAPT (0.66) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL30416772 | 0.80 | MAPT (0.66) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2287907 | 0.80 | NPSR1 (0.63) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL7722815 | 0.79 | NPSR1 (1.00) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL11217129 | 0.79 | NPSR1 (0.63) | NPSR1MAPTKDM4ELMNASMN1; SMN2 | |
| SCHEMBL10310301 | 0.78 | NPSR1 (0.69) | NPSR1MAPTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268419-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |
| WO-2001072705-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-04 | — | — | WO | disclosed |