Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | WEE1 | P30291 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | TDO2 | P48775 | 6/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13302269 | 0.90 | DYRK1A (0.55) | HTR2CDYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL9268634 | 0.86 | NR4A2 (0.68) | NR4A2TDO2IDO1HTR1AHTR2A | |
| SCHEMBL31140515 | 0.83 | WEE1 (0.49) | HTR2CWEE1DYRK1AHTR1AHTR2A | |
| SCHEMBL5435851 | 0.82 | HTR2C (0.56) | HTR2CHTR1AHTR2AHTR2BHTR3E | |
| SCHEMBL2361461 | 0.80 | NR4A2 (0.60) | NR4A2TDO2HTR1AHTR2AHTR1D | |
| SCHEMBL13302385 | 0.80 | ESR2 (0.49) | HTR2CDYRK1ATDO2DYRK2DYRK1B | |
| SCHEMBL9274097 | 0.80 | NR4A2 (0.60) | NR4A2DYRK1ATDO2HTR1AHTR2A | |
| SCHEMBL32678326 | 0.80 | NR4A2 (0.60) | NR4A2TDO2CLK1HTR1AHTR2A | |
| SCHEMBL32678324 | 0.80 | NR4A2 (0.60) | NR4A2TDO2CLK1HTR1AHTR2A | |
| SCHEMBL30954364 | 0.78 | NR4A2 (0.54) | NR4A2TDO2IDO1TSHRHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |