Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 9/20 | 0.77 |
| ▸ | CHRM2 | P08172 | 11/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200135 | 0.99 | CHRM2 (0.79) | CHRM2CHRM1 | |
| SCHEMBL6197920 | 0.99 | CHRM2 (0.79) | CHRM2CHRM1 | |
| SCHEMBL6199519 | 0.99 | CHRM2 (0.79) | CHRM2CHRM1 | |
| SCHEMBL6197212 | 0.93 | CHRM2 (0.78) | CHRM2CHRM1 | |
| SCHEMBL6200890 | 0.87 | CHRM2 (1.00) | CHRM2CHRM1 | |
| SCHEMBL6196106 | 0.87 | CHRM2 (1.00) | CHRM2CHRM1 | |
| SCHEMBL6196400 | 0.87 | CHRM2 (1.00) | CHRM2CHRM1 | |
| SCHEMBL8187619 | 0.87 | CHRM2 (1.00) | CHRM2CHRM1 | |
| SCHEMBL6200532 | 0.85 | CHRM2 (0.82) | CHRM2CHRM1 | |
| SCHEMBL6195849 | 0.85 | CHRM2 (0.82) | CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0910566-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 2003-09-17 | — | — | EP | claimed |
| EP-0910566-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-04-28 | — | — | EP | claimed |
| WO-1997040045-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-10-30 | — | — | WO | claimed |
| EP-0910566-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 2003-09-17 | — | — | EP | disclosed |
| US-6083957-A | FOR TREATMENT OF GLAUCOMA, GASTROINTESTINAL MOTILITY DISORDERS, IRRITABLE BOWEL SYNDROME (IBS), URINARY BLADDER DISORDERS AND RESPIRATORY DISORDERS | NOVO NORDISK A/S (DK) | 2000-07-04 | — | — | US | disclosed |
| EP-0910566-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-04-28 | — | — | EP | disclosed |
| WO-1997040045-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-10-30 | — | — | WO | disclosed |