Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 16/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979066 | 0.86 | CXCR2 (0.66) | CXCR2 | |
| SCHEMBL6978963 | 0.83 | CXCR2 (0.71) | CXCR2 | |
| SCHEMBL6983027 | 0.80 | CXCR2 (1.00) | CXCR2 | |
| SCHEMBL6975666 | 0.80 | CXCR2 (0.64) | CXCR2 | |
| SCHEMBL6978388 | 0.78 | CXCR2 (0.64) | CXCR2 | |
| SCHEMBL6976331 | 0.75 | CXCR2 (0.74) | CXCR2 | |
| SCHEMBL6699911 | 0.73 | CXCR2 (0.55) | CXCR2TDP1P2RX7 | |
| SCHEMBL6695523 | 0.73 | CXCR2 (0.57) | CXCR2TDP1 | |
| SCHEMBL6694431 | 0.73 | CXCR2 (0.68) | CXCR2 | |
| SCHEMBL6970457 | 0.72 | CXCR2 (0.74) | CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109790-B1 | 1, 2, 4-TRIAZOLE-3-THIONE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | claimed |