Methane

Methane

SCHEMBL6982432

C.Cc1ccc(S(=O)(=O)OCC2CO2)cc1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 1/20 0.52
WDR77 Q9BQA1 1/20 0.52
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
ALDH1A1 P00352 6/20 0.49
PKM P14618 2/20 0.49
GAA P10253 2/20 0.49
LMNA P02545 2/20 0.49
CYP2D6 P10635 4/20 0.45
CYP3A4 P08684 3/20 0.45
CYP2C19 P33261 3/20 0.45
TSHR P16473 2/20 0.45
CYP2C9 P11712 2/20 0.45
MAPT P10636 1/20 0.45
MAPK1 P28482 1/20 0.45
GLA P06280 1/20 0.40
STAT3 P40763 1/20 0.40
CYP1A2 P05177 1/20 0.39
SLC12A2 P55011 1/20 0.39
SLC12A5 Q9H2X9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL439063 0.98 PRMT5 (0.54) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL450879 0.98 PRMT5 (0.54) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL439062 0.98 PRMT5 (0.54) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL3744218 0.91 PRMT5 (0.48) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL8065579 0.91 PRMT5 (0.48) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL3744219 0.91 PRMT5 (0.48) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL3745429 0.91 PRMT5 (0.48) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL8068113 0.91 PRMT5 (0.48) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL3748651 0.91 PRMT5 (0.48) PRMT5WDR77MEN1KMT2AALDH1A1
SCHEMBL25305831 0.90 PRMT5 (0.47) PRMT5WDR77MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed
EP-0923575-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS Takeda Chemical Industries, Ltd. (JP) 1999-06-23 EP disclosed
WO-1998008842-A1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-05 WO disclosed