Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990899 | 0.88 | KMT2A (0.50) | SMN1; SMN2TSHRKMT2AMEN1CYP1A2 | |
| SCHEMBL2982271 | 0.72 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1TSHRKMT2AMEN1 | |
| SCHEMBL6989653 | 0.68 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPK1TSHRKMT2AMEN1 | |
| SCHEMBL6989103 | 0.68 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPK1TSHRKMT2AMEN1 | |
| SCHEMBL3158236 | 0.67 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPK1TSHRKMT2AMEN1 | |
| SCHEMBL6983211 | 0.66 | TSHR (0.49) | SMN1; SMN2MAPK1TSHRKMT2AMEN1 | |
| SCHEMBL6989125 | 0.65 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1TSHRKMT2AMEN1 | |
| SCHEMBL6992720 | 0.65 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1TSHRKMT2AMEN1 | |
| SCHEMBL1168717 | 0.65 | MAPT (0.41) | SMN1; SMN2MAPK1KMT2AMEN1CYP3A4 | |
| SCHEMBL6986886 | 0.64 | KMT2A (0.54) | SMN1; SMN2TSHRKMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | claimed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | claimed |