Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986505 | 0.83 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL4030302 | 0.80 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6987581 | 0.80 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6679555 | 0.78 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL8363167 | 0.77 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6607572 | 0.76 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6608672 | 0.76 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6634457 | 0.76 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6633535 | 0.75 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6636787 | 0.74 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363635-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | Merck & Co., Inc. (US) | 2003-11-26 | — | — | EP | disclosed |
| EP-1244628-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2002-10-02 | — | — | EP | disclosed |
| WO-2002069970-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | MERCK & CO., INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| WO-2001046151-A1 | SUBSTITUTED 8-ARYLQUINOLINE PHOSPHODIESTERASE-4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-06-28 | — | — | WO | disclosed |