Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 13/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668863 | 0.93 | F2 (0.55) | F2HDAC1HDAC8 | |
| SCHEMBL7667594 | 0.93 | F2 (0.55) | F2HDAC1HDAC8NR1I2CNR2 | |
| SCHEMBL7672536 | 0.92 | F2 (0.49) | F2HDAC1HDAC8CNR2 | |
| SCHEMBL7670502 | 0.92 | F2 (0.54) | F2HDAC1HDAC8NR1I2CNR2 | |
| SCHEMBL7672461 | 0.91 | F2 (0.53) | F2HDAC1HDAC8NR1I2CNR2 | |
| SCHEMBL7664418 | 0.91 | F2 (0.53) | F2HDAC1HDAC8 | |
| SCHEMBL7671039 | 0.91 | F2 (0.53) | F2HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL6976898 | 0.90 | F2 (0.49) | F2HDAC1HDAC8CNR2 | |
| SCHEMBL7670115 | 0.90 | F2 (0.52) | F2HDAC1HDAC8CNR2 | |
| SCHEMBL7675539 | 0.89 | F2 (0.52) | F2HDAC1HDAC8NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220844-B1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-04-09 | — | — | EP | disclosed |
| US-6365584-B1 | FOR PROPHYLAXIS AND THERAPY OF INFLAMMATORY AND/OR ALLERGIC DISEASES, LUNG FIBROSIS, FIBROSING ALVEOLITIS AND SCARRING, COLLAGENOSES SUCH AS LUPUS ERYTHEMATODES AND SCLERODERMIA AS WELL AS ARTERIOSCLEROSIS, PSORIASIS AND NEOPLASM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-04-02 | — | — | US | disclosed |